Publications
Postdoctoral Publications
* indicates co-first authors.
† indicates co-corresponding authors.
11
Weaver, T.M.*, Ryan, B.J.*, Thompson, S.H., Hussen, A.S., Spencer, J.J., Xu, Z., Schnicker, N.J., and Freudenthal, B.D. (2024) Structural basis for gap-filling DNA synthesis in the nucleosome by DNA polymerase Beta. BioRxiv (Preprint).
10
Kaur, M., Chen, X., Lee, S.Y., Weaver, T.M., Freudenthal, B.D., Walters, K.J., Roelofs, J. (2024) Structure of Blm10:13S proteasome intermediate reveals parallel assembly pathways for the proteasome core particle. BioRxiv (Preprint).
9
Cordero, C.,*, Mehta, K.P.M.*†, Weaver, T.M.*, Ling, J.A., Freudenthal, B.D.†, Cortez, D.†, and Roberts, S.A.† (2024) Contributing factors to the oxidation-induced mutational landscape in human cells. Nature Communications. PMID: 39715760.
8
Schnable, B.L., Schaich, M.S., Roginskaya, V., Leary, L.P., Weaver, T.M., Freudenthal, B.D., Drohat, A.C., Van Houten, B. (2024) Single-molecule analysis reveals TDG exhibits multiple modes of linear diffusion to process 5-formylcytosine. Nature Communications. PMID: 39455577.
7
Ramakrishnan, N., Weaver, T.M., Aubuchon, L.N., Woldegerima, A., Just, T., Song, K., Vindigni, A., Freudenthal, B.D., Verma, P. (2024) Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCA mutant cancer cells. Nature Communications. PMID: 39068174.
6
Schaich, M.S., Weaver, T.M., Freudenthal, B.D., and Van Houten, B. (2024) Single-molecule analysis of purified proteins and nuclear extracts: insights from 8-oxoguanine DNA glycosylase 1. DNA Repair (Amst). PMID: 38237481.
5
Ryan, B.J.*, Weaver, T.M.*, Spencer, J.J., and Freudenthal, B.D. (2023) Generation of recombinant nucleosomes containing site-specific DNA damage. Methods in Molecular Biology. PMID: 37574475.
4
Weaver, T.M., Washington, M.T.†, and Freudenthal, B.D.† (2022) New insights into DNA polymerase mechanisms provided by time-lapse crystallography. Current Opinion in Structural Biology. Perspective. PMID: 36174287.
3
Weaver, T.M., Hoitsma, N.M., Spencer, J.J., Gakhar, L., Schnicker, N.J., and Freudenthal, B.D. (2022) Structural basis for APE1 processing DNA damage in the nucleosome. Nature Communications. PMID: 36104361.
2
Weaver, T.M., Click, T.H., Khoang, T.H., Washington, M.T., Agarwal, P.K.†, and Freudenthal, B.D.† (2022) Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1. Nature Communications. PMID: 35610266.
1
Weaver, T.M.*, Cortes, L.M.*, Khoang, K., Aggarwal, P., and Freudenthal, B.D. (2020) Visualizing Rev1 catalyze protein-template DNA synthesis. Proceedings of the National Academy of Sciences. PMID: 32999062.
Graduate Publications
* indicates co-first authors.
† indicates co-corresponding authors.
7
Suh, J.L., Bsteh, D., Si, Y., Hart, B., Weaver, T.M., Pribitzer, C., Lau, R., Soni, S., Ogana, H., Rectenwald, J.M., Norris, J.L., Cholensky, S.H., Sagum, C., Umana, J.D., Li, D., Hardy, B., Bedford, M.T., Mumenthaler, S.M., Lenz, H., Kim, Y., Wang, G.G., Pearce, K.H., James, L.I., Kireev, D.B., Musselman, C.A., Frye, S.V., and Bell, O. (2021) Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chemical Biology. PMID: 34715055.
6
Wang, S., Denton, K.E., Hobbs, K.F., Weaver, T.M., McFarlane, J.M.B., Connelly, K.E., Gignac, M.C., Milosevich, N., Hof, F., Paci, I., Musselman, C.A., Dykhuizen, E.C., and Krusemark, C.J. (2020) Optimization of Ligands Using Focused DNA-Encoded Libraries to Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor. ACS Chemical Biology. PMID: 31755685.
5
Connelly, K.E.*, Weaver, T.M.*, Alpsoy, A., Gu, B.X., Musselman, C.A.†, and Dykhuizen, E.C.† (2019) Engagement of DNA and H3K27me3 by the CBX8 chromodomain drives chromatin association. Nucleic Acids Research. PMID: 30597065.
4
Weaver, T.M., Liu, J., Connelly, K.E., Coble, C., Varzavand, K., Dykhuizen, E.C., and Musselman, C.A. (2019) The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail. Scientific Reports. PMID: 30700785.
3
Weaver, T.M.*, Morrison, E.A.*, and Musselman, C.A. (2018) Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains. Molecules. Review. PMID: 30322003.
2
Tencer, A.H., Cox, K.L., Di, L., Bridgers, J.B., Lyu, J., Wang, X., Sims, J.K., Weaver, T.M., Allen, H.F., Zhang, Y., Gatchalian, J., Darcy, M.A., Gibson, M.D., Ikebe, J., Li, W., Wade, P.A., Hayes, J.J., Strahl, B.D., Kono, H., Poirier, M.G., Musselman, C.A., and Kutateladze, T.G. (2017) Covalent Modifications of Histone H3K9 Promote Binding of CHD3. Cell Reports. PMID: 29020631.
1
Flenker, K.S., Burghardt, E.L., Dutta, N., Burns, W.J., Grover, J.M., Kenkel, E.J., Weaver, T.M., Mills, J., Kim, H., Huang, L., Owczarzy, R., Musselman, C.A., Behlke, M.A., Ford, B., and McNamara, J.O. 2nd. (2017) Rapid Detection of Urinary Tract Infections via Bacterial Nuclease Activity. Molecular Therapy. PMID: 28391960.